Study Group report
This is the final report on the problem of measuring glucose content in the aqueous humor, brought to ESGI49 by Lein Applied Diagnostics.

Report authors:
Maria Aguareles (Universitat Autònoma de Barcelona)
John Fozard (University of Oxford)
Jens Gravesen (Technical University of Denmark)
Rob Hinch (University of Oxford)
Poul Hjorth (Technical University of Denmark)
Katerina Kaouri (University of Oxford)
David Parker (University of Edinburgh)
Morten Willatzen (University of Southern Denmark)

Introduction
Lein Applied Diagnostics wish to assess the extent to which measuring the glucose concentration in the human body by measuring optically the glucose content of the aqueous humor in the eye is feasible
(i) purely by a system using a linear confocal scan with an LED source, as described below; and
(ii) by supplementing such a system with other suitable measurements.
The Study Group report looked into a number of different methods that potentially could provide the necessary measurement of the glucose level in the aqueous humor. It investigated the original proposal by Lein to measure the optical depth at two different wavelengths and also considered the case where one of the optical measurements is replaced by an acoustic measurement. In the above approach the key feature is the distance between the reflected signals, but the intensity of the signals depends on the glucose concentration too. The possibility of utilizing this effect is also investigated. Another possible method considered is method to measure the refractive index, and thus the glucose concentration, of the aqueous humor by determining the incident ray that leads to total internal reflection. Finally, the report discussed whether the glucose concentration can be determined from the impact of the glucose level on the eyesight.

Download 'Glucose.pdf' (752 Kb).