The objective of this Industrial CASE PhD project is to improve the design and analysis of clinical trials in pharmacogenetics for targeted medicine. Statistical study design, patient recruitment and drug supply planning are usually considered independently of each other. This work will combine insights from various fields (genetics, pharmacology, decision analysis, random effect modelling and stochastic optimisation) to investigate interconnections between the components in order to help drug companies deliver new medicine targeted at subgroups who can best respond to treatment.

Project staff and support

Karen McTeague (Postgraduate Associate, University of Glasgow)
Stephen Senn (Academic supervisor, University of Glasgow)
Vladimir Anisimov (Industrial supervisor, GlaxoSmithKline)
Paul Munday (Technology Translator, Industrial Mathematics KTN)

This project is being carried out at the University of Glasgow, in conjunction with GlaxoSmithKline. It is supported by an EPSRC industrial CASE award, made available through the Knowledge Transfer Network for Industrial Mathematics. Start date: October 2010; duration: 3.5 years.